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Johnson & Johnson to Acquire $2 Billion Drug Developer “Ambrx Biopharma” to Treat Turbo Cancers with Same Tech as Pfizer’s $43 Billion Seagen Acquisition
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Jan. 8, 2024 (CNBC) – J&J to acquire cancer drug developer Ambrx Biopharma for $2 billion
- Johnson & Johnson said it will acquire Ambrx Biopharma for $2 billion, picking up a drugmaker specializing in one of the hottest areas of cancer treatment.
- The deal makes J&J the latest drugmaker to bet on antibody-drug conjugates, or ADCs (same tech as Pfizer’s latest $43 billion Seagen acquisition)
- The acquisition also comes as J&J scrambles to fill a revenue hole that’s approaching in 2025 (!)
- Johnson & Johnson on Monday said it will pay $2 billion in cash to acquire Ambrx Biopharma
- “Ambrx’s pipeline and ADC platform present exciting future opportunities to deliver enhanced, precision biologics as we look to transform the treatment of cancer and improve patients’ lives”
- Under the terms of the deal, J&J will pay $28 a share for Ambrx, or about DOUBLE the firm’s Friday closing price of $13.63. J&J expects to close the deal in the first half of 2024.
- Johnson & Johnson announced the acquisition of Ambrx Biopharma for $2 billion, aiming to boost its oncology pipeline with Ambrx’s innovative antibody drug conjugates
- This strategic move focuses on targeted therapies like ARX517 for prostate cancer
- ADCs, a class of therapeutics that combines the specificity of monoclonal antibodies with the potency of cytotoxic drugs, aiming to target and destroy cancer cells more effectively
- The jewel in Ambrx’s crown is ARX517, their proprietary ADC targeting Prostate-Specific Membrane Antigen (PSMA) for treating metastatic castration-resistant prostate cancer (mCRPC)
- In addition to ARX517, Ambrx’s portfolio includes other promising ADCs like ARX788, targeted at HER2+ metastatic breast cancer
- ARX305, its proprietary ADC targeting CD-70 for renal cell carcinoma.
- Johnson & Johnson (NYSE: JNJ) announced today it has entered into a definitive agreement to acquire Ambrx Biopharma, Inc., or Ambrx, a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform to design and develop next-generation antibody drug conjugates (ADCs), in an all-cash merger transaction for a total equity value of $2.0 billion
- results seen to date with ARX517 in mCRPC (prostate cancer) are promising and represent a potential first- and best-in-class targeted therapy for the treatment of this aggressive disease.
- Ambrx’s proprietary ADC technology incorporates the advantages of highly specific targeting monoclonal antibodies securely linked to a potent chemotherapeutic payload to achieve targeted and efficient elimination of cancer cells without the prevalent side-effects typically associated with chemotherapy
- Following completion of the transaction, Ambrx’s common stock will no longer be listed for trading on the NASDAQ Global Select Market.
This is my original prediction about COVID-19 mRNA Vaccine Induced Turbo Cancers, which may change slightly over time as more data comes in.
Top 5 Turbo Cancers by # of people who will be affected long term:
- Lymphoma (various types)
- Brain Cancers (mostly glioblastoma)
- Breast Cancer (mostly triple negative)
- Colon Cancer
- Lung Cancer
- leukemias
- melanomas
- sarcomas
- testicular/ovarian
- kidney
- Pfizer has positioned itself to be able to treat 7 of the top 10 Turbo Cancers as I have identified at this early stage.
- Seagen added ADC cancer drugs (or drugs in pipeline) to Pfizer to treat: lymphoma, breast, colorectal, lung, as well as cancers not in my top 10: cervical, urothelial bladder and multiple myeloma.
- This $2 billion acquisition gives J&J the ability to use the same ADC technology as Pfizer’s $43 billion Seagen, to treat 2 of the top 10 turbo cancers: breast cancer and kidney cancer.
- I have not seen a major spike in prostate cancer yet, but they may know something I don’t.
Many pharmaceutical companies are rushing to position themselves to profit from treating a tsunami of cancers that they are all expecting to hit starting in 2025.
- Dec. 14, 2023 – Pfizer closed a $43 billion acquisition to treat several turbo cancers on Dec.14, 2023 and expects to “fill a gap” for the period 2025-2030.
- Dec. 14, 2023 – Moderna targets new mRNA Cancer vaccine to treat melanoma to be available by 2025
- Jan. 8, 2024 – Johnson & Johnson to acquire $2 billion cancer drug company that uses same tech as Pfizer, to “fill a revenue gap in 2025”
- Jan. 10, 2024 – BioNTech expects to return to revenue growth in 2025, when its COVID vaccine business would bottom out, and it would invest to “scale up its oncology business thereafter”
- Oct.12, 2023 – Dxcover targets 2025 launch for blood test that uses light to detect brain cancer
- Sep.2023 – Harbinger Health raises $140M to study blood-based cancer screening test – ahead of a planned launch in 2025.
- Jun.1, 2023 – Multi-cancer blood test shows real promise in NHS study – NHS in England plans to extend the rollout to a further one million people in 2024 and 2025
Cancer Centers to Open by 2025
- Aug. 2023 – Cape Breton (NS, Canada) Cancer centre to open in 2025
- Jul. 2023 – $120M Cancer center (Tennessee Oncology) set for 2025 finish
- Jun. 2023 – $200M Cancer center set to open in NJ in 2025
- Mar. 2023 – Orange County’s only cancer specialty hospital will open in 2025
- May 2023 – Kearney, Nebraska to welcome new cancer center in 2025
- Jan. 2023 – OU Health to open cancer center in 2025
- Dec. 2022 – $2 billion Alberta, Canada cancer centre to open in 2024
- Aug. 2022 – Baltimore, MD – Sinai Hospital to build cancer center by 2025
- Jul. 2022 – Wales – New Velindre cancer centre to open in 2025
- Dec. 2023 – 123 cancer centers opening, expanding, affiliating in 2023
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Dr. William Makis is a Canadian physician with expertise in Radiology, Oncology and Immunology. Governor General’s Medal, University of Toronto Scholar. Author of 100+ peer-reviewed medical publications.
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