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Papers reviewed

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2021 Dec (Mitchell et al) – Appendicitis as a possible safety signal for the COVID-19 vaccines

• 334 cases of post COVID-19 Vaccine appendicitis identified in the WHO VigiAccess database


• 69% needed surgical intervention


• 301 (90%) were marked as serious


• 283 (85%) caused or prolonged hospitalization


• 87 (26%) were life threatening


• 6 (2%) persistent or significant disability


• 1 (0.3%) fatal


• median time was 4 days after COVID-19 Vaccination, range 0 to 71 days

• Appendicitis occurs commonly due to obstruction of appendiceal lumen, can be due to a fecalith or lymphoid hyperplasia.


• 161 (48%) had imaging to support the diagnosis


• Theory: COVID-19 vaccines produce robust Th1 immune responses and there is a hypothesised link between an increased Th1 immune response and a sub-type of appendicitis that is likely to require surgery


• 49% were in age group 18-44, 31% were in 45-64, median age 42 years old.

2022 May (Marconi et al) – Acute appendicitis in a patient immunised with COVID-19 vaccine: A case report with morphological analysis

• 58F healthcare professional had 1st Pfizer mRNA two days prior to onset


• presented in ER with pain, fever, nausea and vomiting


• CT scan with contrast disclosed a distended appendix (maximum thickness 12 mm) with thickened walls, typical of acute appendicitis.


• patient had a video-laparoscopic appendectomy

2022 June (Oganesyan et al) – Acute appendicitis following the COVID-19 vaccine

• 69F developed appendicitis 3 days after 3rd Pfizer mRNA dose


• Had fever 12hr after Pfizer, abdominal pain 24hr after Pfizer


• CT showed perforated acute appendicitis with appendicolith visualized at base of appendix with associated mesenteric fat stranding, multi-loculated free fluid and trace free air.


• Diagnosis: perforated appendicitis, had surgery.

2023 Jan (Jambon-Barbara et al) – Understanding the variability of pharmaco‐epidemiological studies assessing the risk of appendicitis with mRNA COVID‐19 vaccines

As of Nov. 16, 2023, WHO VigiAccess Database reports:

• 2555 cases of Appendicitis


• 700 Appendicectomy

Kids affected (32 results in VAERS on “appendicitis” under age 12, 31/32 are Pfizer, few examples include):

• VAERS 1906934 – 10 year old boy from Connecticut had 1st Pfizer mRNA on Nov. 22, 2021. Four days later he developed appendicitis requiring surgery.


• VAERS 1909640 – 5 year old girl from Illinois, had 1st Pfizer mRNA on Nov. 16, 2021, developed fever, very lethargic and right quadrant pain 8 days later with MRI showing fluid around her appendix. 


• VAERS 1931574 – 7 year old boy from California, had 2nd Pfizer mRNA on Dec. 3, 2021. Four days later developed appendicitis requiring surgery.


• VAERS 1932534 – 6 year old girl from Kansas, had 1st Pfizer mRNA on Nov. 27, 2021. Next day developed vomiting, pain, diagnosed with appendicitis, surgery on Dec.3, 2021 revealed perforated appendix. 


• VAERS 1951315 – 11 year old boy from Georgia had 1st Pfizer mRNA on Nov. 19, 2021, developed appendicitis 11 days later requiring surgery.


• VAERS 2651258 – 1.67 year old (20 month old) girl from New York had 1st Moderna mRNA on June 29, 2022. She had appendicitis where her appendix ruptured, requiring surgery on March 23, 2023.

CDC Communications:

Appendix Cancer (Turbo Cancer)

Nov. 7, 2023 – Thunder Bay, ON – 20s year old Hannah Deley had months of severe abdominal pain, and after appendix surgery was found to have Stage 4 Appendix Cancer with small lesions throughout her lungs.

Oct. 29, 2023 – Utica, MI – Timothy Sexton had beaten Stage 4 Colorectal cancer and was in remission for 3 years since June 2020. However, in 2023, his cancer returned, much more rare and aggressive – it returned in his Appendix. Despite surgeries & treatment, it’s spreading.

Sep. 29, 2023 – Jessup, MD – 43 year old Pamela Harrison had stomach pains and was rushed to have her appendix removed on Sep. 15, 2023. “My appendix came back fully covered in Stage 4 cancer”. Now needs to have 80% of her colon removed.

Aug. 14, 2023 – Wellington, FL – Sharika Moss was found to have a 10-15cm mass behind her uterus. It was cancer of the appendix and intestines.

June 18, 2023 – Dallas, TX – 40s year old Home Care Nurse Eber Delgado was diagnosed with Stage 4 Appendix Cancer and needs a major surgery.

According to CDC and FDA, appendicitis was the most common Serious Adverse Event (non-fatal) for the Pfizer COVID-19 mRNA Vaccine Trial.

FDA suggested more studies, so 3 major studies were done and they were sponsored by either Pfizer, CDC or Astrazeneca (and a few other big pharma companies).

Understandably, they found no link between COVID-19 mRNA Vaccines and appendicitis, and their financial sponsors were satisfied.

2500 reported cases of Appendicitis in WHO VigiAccess, times an under-reporting factor of 100, means potentially 100,000s of cases worldwide.

Does this seem like an acceptable “Serious Adverse Event”?

• 90% were classified as serious


• 85% were hospitalized


• 26% were life-threatening


• 2% were disabled


• 0.3% died


• dozens of children under age 12 injured in VAERS requiring surgery, including a 20 month old girl from New York with a ruptured appendix after Moderna mRNA Vaccine.

My concern is specifically regarding Turbo Cancers of the Appendix.

Appendix cancers are extremely rare (1 in a million), but they’re starting to show up at Stage 4, in young people, large tumors, extremely aggressive, just like other Turbo Cancers I’ve been writing about.

CDC Official wrote: “The Vaccine clearly causes hyperplasia of lymphoid tissue and that could cause appendicitis and small bowel obstruction”. Yeah, in the short term. What about the LONG TERM?

Can COVID-19 mRNA Vaccines cause Stage 4 Turbo Cancers of the Appendix? Although the information is very preliminary, I believe they do. 

That means children and young adults are at risk of yet another Turbo Cancer.

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Dr. William Makis is a Canadian physician with expertise in Radiology, Oncology and Immunology. Governor General’s Medal, University of Toronto Scholar. Author of 100+ peer-reviewed medical publications.

Featured image is from Dr. Rath Health Foundation

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